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KMID : 0931320180180010038
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대한상부위장관.헬리코박터학회지
2018 Volume.18 No. 1 p.38 ~ p.49
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Randomized, Double-blind, Placebo-controlled Clinical Trial for the Evaluation of the Efficacy and Safety of Artemisia and Green Tea Extract SD1003F in Volunteers with Helicobacter pylori-associated Gastric Discomfort
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Kwon Sang-Oh
Kwak Dong-Yun
Hong Sung-Pyo
Kim Won-Hee
Park Jong-Min
Han Young-Min
Kang You
Kang Eun-A
Jo Seo-Hyun
Hahm Ki-Baik
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Abstract
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Background/Aims: A previous study showed that dietary intervention with Artemisia and green tea extracts, i.e., SD1003F, relieved Helicobacter pylori-associated chronic atrophic gastritis in a mouse model. We continue the research through the current randomized double-blind clinical trial to evaluate the efficacy and safety of the intervention for H. pylori-associated gastric discomfort.
Materials and Methods: Forty-nine volunteers who tested positive for H. pylori infection received either placebo or SD1003F for 10 weeks and their functional dyspepsia-related quality of life (QOL) was evaluated. H. pylori infection using a urea breath test (UBT), measurement of pepsinogen level using GastroPanel. Adverse effects with biochemical changes were also evaluated.
Results: SD1003F administration significantly improved health related-QOL, including dietary intake, emotional stability, life pattern, and social factors relevant to gastric discomfort, in comparison to the control (P＜0.05). The mean UBT measurement significantly decreased in the SD1003F group (P＜0.05). In 2 of the 24 volunteers, SD1003F alone eradicated H. pylori infection, with significant improvements in endoscopic findings. GastroPanel analysis revealed significant improvements that reflect rejuvenation of gastric atrophy in the SD1003F group. No significant side effect was observed in any participant.
Conclusions: SD1003F (Artemisia and green tea extract), is a potential phytochemical to improve H. pylori-associated gastric discomfort.
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KEYWORD
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Artemisia, Atrophy, Functional dyspepsia, Green tea, Helicobacter pylori
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